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SANT-1

SKU: orb1225366

Description

SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.

Images & Validation

Key Properties

CAS Number304909-07-7
MW373.49
Purity>98% (HPLC)
FormulaC23H27N5
SMILESCC1=C(/C=N/N2CCN(CC3=CC=CC=C3)CC2)C(C)=NN1C4=CC=CC=C4
TargetHedgehog (Hh)
SolubilityEthanol: 20 mg/mL (53.54 mM); DMSO: 21 mg/mL (56.22 mM)

Bioactivity

In Vitro
Cell Viability Assay Cell line: Medulloblastoma cells. Concentration: 1 μM. Incubation time: 24 hours or 48 hours. Result: Inhibited cellular proliferation in primary tumorspheres.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SANT-1 | SANT 1 | SANT1

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Protocol Information

Available Sizes

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200 mg
500 mg
2 mg
$ 70.00
5 mg
$ 90.00
10 mg
$ 140.00
25 mg
$ 220.00
50 mg
$ 340.00
100 mg
$ 580.00