Saponarin

SKU: orb1684240

Description

Saponarin (Petrocomoside) demonstrates hepatoprotective and antioxidant effects in both in vitro and in vivo models, specifically against carbon tetrachloride (CCl4)-induced hepatic injury. This flavonoid glucoside is a valuable research tool for studying liver protection mechanisms, oxidative stress, and phytotherapeutic interventions in pharmacology and toxicology.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Neuroscience, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	20310-89-8
MW	594.52
Purity	98.84% (May vary between batches)
Formula	C₂₇H₃₀O₁₅
SMILES	OC[C@H]1O[C@@H](Oc2cc3oc(cc(=O)c3c(O)c2[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)-c2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Target	COX,PERK,p38 MAPK,ERK,NF-κB,Cytochromes P450,Interleukin,AMPK
Solubility	DMSO:90 mg/mL (151.38 mM)

Bioactivity

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In Vitro

In freshly isolated rat hepatocytes, paracetamol (100 μ mol) led to a significant decrease in cell viability, increased LDH leakage, decreased levels of cellular GSH, and elevated MDA quantity. Saponarin (60-0.006 μ g/mL) preincubation, however, significantly ameliorated paracetamol-induced hepatotoxicity in a concentration-dependent manner. The beneficial effect of Saponarin was also observed in vivo. Rats were challenged with paracetamol alone (600 mg/kg, i.p.) and after 7-day pretreatment with Saponarin (80 mg/kg, oral gavage). Paracetamol toxicity was evidenced by increase in MDA quantity and decrease in cell GSH levels and antioxidant defence system. No changes in phase I enzyme activities of AH and EMND and cytochrome P 450 quantity were detected. Saponarin pretreatment resulted in significant increase in cell antioxidant defence system and GSH levels and decrease in lipid peroxidation. The biochemical changes are in good correlation with the histopathological data. Protective activity of Saponarin was similar to the activity of positive control silymarin.

Storage & Handling

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Storage	store at low temperature,keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Isovitexin-7-O-glucoside, P450, NFκB, NF-κB, NFkB, NF-kB, ERK, Petrocomoside, Saponaretin-7-O-glucoside, Saponarin

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Compound Identifiers

PubChem CID

441381 ↗

Key Properties

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No computed properties available.

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Saponarin (orb1684240)

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Purity:	>98% (HPLC)
CAS Number:	35450-86-3
MW:	610.52
Formula:	C₂₇H₃₀O₁₆

Saponarin

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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