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Saquinavir

SKU: orb1299397

Description

Saquinavir (Ro 31-8959) is a small molecule HIV-1 protease inhibitor used as an antiretroviral agent. It is widely applied in biochemical research to study viral replication mechanisms and evaluate combination therapies in both cellular and animal models of HIV infection.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Images & Validation

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Saquinavir

Key Properties

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CAS Number127779-20-8
MW670.84
Purity>99.99% (May vary between batches)
FormulaC38H50N6O5
SMILESCC(C)(C)NC(=O)C1CC2CCCCC2CN1CC(O)C(Cc1ccccc1)NC(=O)C(CC(N)=O)NC(=O)c1ccc2ccccc2n1
TargetInterleukin,SARS-CoV,ROS,HIV Protease,NO Synthase,Calcium Channel,p38 MAPK,Apoptosis,TLR,JNK
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (7.45 mM);DMSO:260 mg/mL (387.57 mM)

Bioactivity

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In Vivo
The AUC was not affected by grapefruit juice after intravenous administration, but it increased significantly from 76+/-96 (water, mean (s.d.) to 114+/-70 (microg l[-1] h) (grapefruit juice) after oral saquinavir. Similarly, the oral bioavailability of saquinavir increased by a factor of 2 with grapefruit juice (from 0.7% to 1.4%). In contrast, clearance, volume of distribution and elimination half-life of saquinavir were not affected by grapefruit juice. After oral, but not after intravenous administration, the plasma concentration-time curve showed a second peak after lunch irrespective of pretreatment, suggesting enhancement of absorption by food.
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Animal Research
After an overnight fast, eight healthy volunteers were treated with either 400 ml grapefruit juice or water before intravenous (12 mg) or oral saquinavir (600 mg) was administered. Serial blood samples were obtained over the following 24 h and standardized meals were served 5 and 10 h after the administration of saquinavir. The plasma concentrations of saquinavir were determined by high-performance liquid chromatography and pharmacokinetic parameters were calculated by routine methods.
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Storage & Handling

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StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Ro 31-8959, SARS coronavirus, Saquinavir, SARS-CoV, SARSCoV, inhibit, Inhibitor, Human immunodeficiency virus, HIV, HIVProtease, HIV Protease

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  • Saquinavir mesylate

    Saquinavir mesylate [orb1685420]

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    C39H54N6O8S

    1 ml x 10 mM (in DMSO), 5 mg
Quality Guarantee

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Compound Identifiers

PubChem CID
3579812 ↗

Key Properties

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No computed properties available.

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Saquinavir (orb1299397)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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5 mg
¥ 1,040.00
1 ml x 10 mM (in DMSO)
¥ 1,300.00
10 mg
¥ 1,300.00
50 mg
¥ 2,990.00
DispatchUsually dispatched within 3-5 working days
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