Saralasin acetate(34273-10-4 free base)

SKU: orb1218067

Description

Saralasin acetate is a Non-selective angiotensin II antagonist.

Research Area

Pharmacology & Drug Discovery

Images & Validation

−

Key Properties

−

CAS Number	39698-78-7
MW	990.11
Purity	>98% (HPLC)
Formula	C₄₄H₇₁N₁₃O₁₃
SMILES	CC(C)[C@@H](C(N[C@@H](Cc1cnc[nH]1)C(N(CCC1)[C@@H]1C(N[C@@H](C)C(O)=O)=O)=O)=O)NC([C@H](Cc(cc1)ccc1O)NC([C@H](C(C)C)NC([C@H](CCCN=C(N)N)NC(CNC)=O)=O)=O)=O.CC(O)=O.O
Target	RAAS

Bioactivity

−

In Vivo

Saralasin acetate hydrate (intravenous injection, 5-50 μg/kg, a single dose) ameliorates the oxidative stress and tissue injury in cerulein-induced pancreatitis. Saralasin acetate hydrate (subcutaneous injection, 10 and 30 mg/kg, a single dose) increases serum renin activity (SRA) in normal, conscious rats, without markedly altering blood pressure or heart rate. Animal model: Cerulein-induced acute pancreatitis rats model. Dosage: 5, 10, 20, and 50 μg/kg, a single dose. Administration: Intravenous injection. Result: Restored the pancreatic morphological characteristics to the control level. Reduced pancreatic injury and suppressed the glutathione depletion induced by cerulean. Animal model: Male Sprague-Dawley rats. Dosage: 10 and 30 mg/kg, a single dose. Administration: Subcutaneous injection. Result: Stimulated renin release without altering blood pressure or heart rate at the time of measuring serum renin levels 20 minutes after injection.

In Vitro

Saralasin acetate hydrate (1 nM, 48 or 72 h) inhibits cell growth in 3T3 and SV3T3 cells. Saralasin acetate hydrate (5 μM, 2h) restores Ito, fast (Fast-Inactivating Transient Outward K+ Current in Mouse Ventricle) and I K, slow (Slow-Inactivating Transient Outward K+ Current in Mouse Ventricl) to control levels in myocytes. Saralasin acetate hydrate (0.1-10 nM, 40 min) inhibits binding of FITC-Ang II to rat liver membrane preparation (used as the source of angiotensin receptors) with a Ki value of 0.32 nM for 74% of the binding sites and 2.7 nM for the remaining binding sites. Saralasin acetate hydrate (1 μM, perfused rat ovary in vitro) inhibits the ovulation rate versus control and reduces prostaglandin E2 and 6-keto-prostaglandin F1α levels. Cell Proliferation Assay Cell line: 3T3 and SV3T3 cells. Concentration: 1 nM. Incubation time: 48 h, 72 h. Result: Inhibited cell growth in 3T3 and SV3T3 cells and caused an increase of cellular renin concentration.

Storage & Handling

−

Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Quick Database Links

Gene Symbol

RAAS

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols