Sarcosine

SKU: orb1300297

Description

Sarcosine is a dual-function small molecule that competitively inhibits the glycine transporter GlyT1 and acts as a co-agonist at NMDA receptors. It is widely used in neuroscience research to study glutamatergic neurotransmission, synaptic plasticity, and related mechanisms in models of psychiatric and neurological disorders.

Research Area

Metabolism Research, Neuroscience

Images & Validation

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Key Properties

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CAS Number	107-97-1
MW	89.09
Purity	99.34% (May vary between batches)
Formula	C₃H₇NO₂
SMILES	CNCC(O)=O
Target	Endogenous Metabolite\|\|\|GlyT
Solubility	DMSO:Insoluble;H2O:250 mg/mL (2806.15 mM)

Bioactivity

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In Vivo	Sarcosine has weak anticonvulsant properties. It ameliorates (prepulse inhibition)PPI deficits in mGluR5 knockout mice.
In Vitro	Sarcosine is a GlyR agonist in addition to being a GlyT1 inhibitor and NMDAR co-agonist, but it is less potent than glycine as a GlyR agonist and is not a full agonist. The viability of the sarcosine-treated cells is significantly reduced.
Cell Research	Immediately after the cells grow to 50-60% confluence, the cultivation medium is replaced by fresh medium to synchronise cell growth. Cells are cultivated for 24 h under these conditions. Subsequently, the culture medium is supplemented with sarcosine (N-methylglycine) diluted to a final concentration 10, 150, 250, 500, 1,000 and 1,500 μM. Treatment is carried out for 0, 6, 12, 24 and 72 h, and samples are collected at these strictly defined time points.(Only for Reference)

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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cognitive, depression, dysfunction, Endogenous Metabolite, Methylaminoacetic acid, Methylglycine, N-methyl-D-aspartate, N-methylglycine, N-Methylaminoacetic acid, inhibit, Inhibitor, Glycine transporters, GlyT, GlyT1, EndogenousMetabolite, Sarcosin, Sarcosine, Sarcosinic acid, schizophrenia

Quality Guarantee

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Compound Identifiers

PubChem CID

1088 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

Applications:	ELISA, IHC, WB
Reactivity:	Human, Mouse, Rat
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, IHC, WB
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

MW:	44.1 kDa
Source:	Human

Applications:	IP, WB
Reactivity:	Human, Mouse
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	IP, WB
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Sarcosine

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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