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Sarizotan 2HCl

SKU: orb2281177

Description

Sarizotan 2HCl is a dual-activity research compound, functioning as a 5-HT1A receptor agonist and a hERG channel blocker. It is utilized in preclinical studies investigating Parkinson's disease, particularly for its potential to modulate motor functions and address L-DOPA-induced dyskinesias in both cellular and animal models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number177976-12-4
MW421.34
Purity98.83%
FormulaC22H23Cl2FN2O
SMILESFC(C=C1)=CC=C1C2=CN=CC(CNC[C@@H]3OC4=CC=CC=C4CC3)=C2.Cl.Cl
TargetPotassium Channel,5-HT Receptor,Dopamine Receptor

Bioactivity

Target IC50
5-HT1A receptor:0.1 nM|5-HT2A receptor:587 nM|5-HT6 receptor (human):3300 nM|5-HT7 receptor (human):10 nM|D3 receptor (human):6.8 nM|5-HT5A receptor:313 nM|5-HT2B receptor:108 nM
In Vivo
Compared to rats treated with levodopa alone, Sarizotan 2HCl (10 ng and 1 μg in 0.3 μL solution) administered subthalamicly at higher doses (10 ng and 1 μg) significantly reduced rotational response scores in male Sprague-Dawley rats weighing 220-240 g.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

hERG, 5HT Receptor, 5-HT1A, 5HTReceptor, Sarizotan2HCl
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Sarizotan 2HCl (orb2281177)

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1 mg
¥ 2,080.00
2 mg
¥ 2,860.00
5 mg
¥ 4,290.00
10 mg
¥ 5,980.00
25 mg
¥ 8,970.00
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