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SARM1-IN-4

SKU: orb3028307

Description

SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.

Research Area

Immunology & Inflammation, Neuroscience

Images & Validation

Key Properties

CAS Number3069378-18-0
MW285.29
FormulaC13H17F2N3O2
SMILESN(C(N([C@@H](C)C=1C=CN=CC1)C)=O)[C@H]2C(F)(F)COC2
TargetTLR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information