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SARS-CoV-2-IN-115

SKU: orb3134985

Description

SARS-CoV-2-IN-115 (Compound 3e) is a potent inhibitor of SARS-CoV-2, showing strong antiviral activity in infected Calu-3 cells with an EC50 of 1.7 μM. It effectively inhibits human dihydroorotate dehydrogenase (HsDHODH) activity with an IC50 of 1.5 μM. Importantly, SARS-CoV-2-IN-115 maintains immune response without affecting the proliferation of CD4 T cells.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology

Images & Validation

Key Properties

CAS Number2557232-80-9
MW250.30
FormulaC16H14N2O
SMILESO=C(NC1=CC=C(C#CC2=CC=CC(N)=C2)C=C1)C
TargetDehydrogenase,DNA/RNA Synthesis,SARS-CoV

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information