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SB 206553 hydrochloride

SKU: orb1704095

Description

SB 206553 hydrochloride is a selective 5-HT2C inverse agonist and 5-HT2B antagonist with oral activity. It is used in neuroscience research to study anxiety-related behaviors and receptor functions in both in vitro binding assays and in vivo animal models.

Research Area

Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry

Images & Validation

Key Properties

CAS Number1197334-04-5
MW328.8
Purity99.56% (May vary between batches)
FormulaC17H17ClN4O
SMILESCl.O=C(NC=1C=NC=CC1)N2C3=CC=4C=CN(C4C=C3CC2)C
Target5-HT Receptor,HIV Protease
SolubilityDMSO:25 mg/mL (76.03 mM)

Bioactivity

In Vivo
Intraperitoneal administration of SB 206553 hydrochloride (1-10 mg/kg) caused a dose-dependent increase in DA release from the accumbens and striatum in rats. SB 206553 hydrochloride (1-10mg/kg), only 10mg/kg, enhanced c-Fos expression in STN, striatum (except dorsomedial part), NAcc, inner surface nucleus, substantia nigra reticularis (SNr) and densa (SNc), and ventral tegmental area.
In Vitro
SB 206553 hydrochloride (50 μM) prevented the promotion of mEPSC induced by the application of α-Me-5HT (10 μM), while the rise and decay time constants of mEPSC administered by α-Me-5HT remained unchanged in the presence of SB 206553 hydrochloride.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SB206553 hydrochloride, SB-206553 Hydrochloride
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 100.00
5 mg
$ 170.00
10 mg
$ 240.00
25 mg
$ 440.00
50 mg
$ 620.00
DispatchUsually dispatched within 6-8 weeks
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