SCFSkp2-IN-2

SKU: orb1737461

Description

SCFSkp2-IN-2 is a Skp2 inhibitor with a K_D of 28.77 μM. It induces apoptosis in non-small cell lung cancer (NSCLC) cells, demonstrating antitumor activity in vitro, and serves as a research tool for studying Skp2's role in oncology and cell cycle pathways.

Research Area

Cell Biology, Protein Biochemistry

Images & Validation

−

Key Properties

−

CAS Number	1375060-02-8
MW	312.37
Purity	99.86% (May vary between batches)
Formula	C₁₇H₂₀N₄O₂
SMILES	N(CC)(CC)C1=CC(O)=C(/C=N/NC(=O)C=2C=CC=NC2)C=C1
Target	E1/E2/E3 Enzyme,Apoptosis
Solubility	DMSO:112.5 mg/mL (360.15 mM)

Bioactivity

−

Target IC50	Skp2:28.77 μM(kd)
In Vivo	SCFSkp2-IN-2 (Compound AAA-237) administered at 15 or 45 mg/kg intraperitoneally on a daily basis for 14 days demonstrated antitumor activity in an A549 lung cancer xenograft mouse model. Read more...
In Vitro	SCFSkp2-IN-2 (Compound AAA-237) (0.3-3 μM; 24-72 h) binds directly to Skp2, leading to its proteasome-mediated degradation without affecting Skp2 mRNA expression but inhibiting Skp2 protein expression in a time-dependent manner in NSCLC cells. SCFSkp2-IN-2 inhibits the proliferation of A549 and H1299 cells and induces apoptosis in a dose- and time-dependent manner, blocks the cell cycle at the G0/G1 checkpoint by regulating the Skp2-Cip/Kip and PI3K/Akt-FOXO1 signaling pathways, and induces NSCLC cell senescence (0.3 μM; 1-7 days). Read more...

Storage & Handling

−

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

E3Enzyme, E3 Enzyme, E2 Enzyme, E2Enzyme, E1/E2/E3 Enzyme, E1 Enzyme, E1Enzyme, Apoptosis, SCFSkp2IN2, SCFSkp2-IN-2, Skp2

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

135457298 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

SCFSkp2-IN-2 (orb1737461)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

SCFSkp2-IN-2

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

SCFSkp2-IN-2 (orb1737461)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors