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SCH-336

SKU: orb1702822

Description

SCH-336 is a potent, selective, and orally active CB2 receptor agonist (Ki 1.8 nM) with 100-fold selectivity over CB1. It demonstrates functional activity by inhibiting GTPγS binding, CB2-mediated cell migration in vitro, and attenuating leukocyte migration and pulmonary eosinophilia in murine models of delayed hypersensitivity and allergy.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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SCH-336

Key Properties

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CAS Number447459-51-0
MW539.64
Purity95.01% (May vary between batches)
FormulaC23H25NO8S3
SMILESS(=O)(=O)(C1=C(S(=O)(=O)C2=CC=C(OC)C=C2)C=C(OC)C=C1)C3=CC=C([C@@H](NS(C)(=O)=O)C)C=C3
TargetCannabinoid Receptor
SolubilityDMSO:90 mg/mL (166.78 mM)

Bioactivity

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Target IC50
CB2 (human):2nM(EC50)|CB2 (BaF3 cells):34nM|CB1 (human):200nM(EC50)
In Vivo
In in vivo studies, when administered intraperitoneally (i.p.) at doses of 0.02-2.0 mg/kg, SCH 336 significantly inhibits leukocyte migration .
In Vitro
SCH 336 (also known as Sch.336) exhibits competitive binding with [3H]CP55,940 to human CB2 receptors on Sf9 cell membranes, with a Ki value of 1.8 nM. It reduces GTPγS binding on membranes containing human CB2 receptors, with an EC50 of 2 nM. However, its potency decreases on membranes containing CB1 receptors, with an EC50 of 200 nM . Moreover, SCH 336 inhibits the migration of BaF3/CB2 cells towards 100 nM 2-AG, with an IC50 of 34 nM .

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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CB2, CannabinoidReceptor, Cannabinoid Receptor, SCH-225336, SCH 336, SCH336, SCH-336
Quality Guarantee

Quality Guarantee

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Compound Identifiers

PubChem CID
10324989 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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5 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 100.00
10 mg
$ 120.00
25 mg
$ 210.00
50 mg
$ 280.00
100 mg
$ 390.00
200 mg
$ 540.00
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