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SCH529074

SKU: orb1693218

Description

SCH529074

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number922150-11-6
MW563.56
Purity99.57% (May vary between batches)
FormulaC31H36Cl2N6
SMILESCN(C)CCCNc1nc(CN2CCN(CC2)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)nc2ccccc12
Targetp53,MDM-2/p53
SolubilityDMF:33 mg/mL (58.56 mM);Ethanol:33 mg/mL (58.56 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.77 mM);DMSO:22.5 mg/mL (39.92 mM)

Bioactivity

Target IC50
p53 DBD:1-2 μM (Ki)
In Vivo
In female nude mice, 5–7 weeks of age, received subcutaneous inoculation of DLD-1 human colorectal carcinoma cells, SCH529074 (orally; 30 and 50 mg/kg) reduces 79 and 43% of tumor growth with the plasma exposure of 0.26–0.55 μm at 30 mg/kg and 0.39-0.79 μm at 50 mg/kg.
In Vitro
SCH529074 (2-4 µM) reduces cell viability and decreases to 20-25% in p53 mutant cells including H157, H1975, and H322, and to 68% in the p53 WT cell line A549 at 4 µM. SCH 529074 (2-4 µM) induces NSCLC cells including H157, A549, HCT116, and HCT116 p53-/- arrested at the G0/G1 phase (59%; 72%; 66%; and 57%).

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SCH529074, SCH-529074, SCH 529074, p53
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 70.00
2 mg
$ 80.00
5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 110.00
10 mg
$ 150.00
25 mg
$ 280.00
50 mg
$ 390.00
100 mg
$ 540.00
DispatchUsually dispatched within 5-10 working days
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