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Sciadopitysin

SKU: orb1301256

Description

Sciadopitysin is a research compound studied for its potential to protect against diabetic bone disease by enhancing mitochondrial biogenesis. It has demonstrated protective effects in osteoblast cell models and shown activity against amyloid-beta toxicity in neuronal cultures, indicating relevance for bone and neurodegenerative research.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number521-34-6
MW580.54
Purity99.08%
FormulaC33H24O10
SMILESCOc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)c(-c3cc(ccc3OC)-c3cc(=O)c4c(O)cc(OC)cc4o3)c2o1
TargetNF-κB,TNF
SolubilityDMSO:135 mg/mL (232.54 mM)

Bioactivity

Cell Research
Pretreatment of MC3T3-E1 cells with Sciadopitysin prevente the MG-induced cell death and protein adducts formation. Sciadopitysin restore the MG-induced change in glyoxalase activity almost to the control level and increased glutathione levels. In addition, Sciadopitysin decreased MG-induced formation of intracellular Reactive oxygen species (ROS), mitochondrial superoxide, and cardiolipin peroxidation. These findings suggest that Sciadopitysin provides a Protective action against MG-induced glycation by increasing MG detoxification system and by reducing oxidative stress. Pretreatment with Sciadopitysin prior to MG exposure reduced MG-induced mitochondrial dysfunction by preventing mitochondrial membrane potential (MMP) dissipation and adenosine triphosphate (ATP) loss.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

osteoclastogenesis, Sciadopitysin, TNF-α, biloba, Biflavonoids, bone, NF-κB, NF-kB, NFkB, NFκB, Nuclear factor-kappaB, Nuclear factor-κB, loss, inhibit, ginkgo, Inhibitor

Similar Products

  • Sciadopitysin [orb1222121]

    >98% (HPLC)

    521-34-6

    580.5

    C33H24O10

    1 g, 10 mg, 25 mg, 50 mg, 100 mg, 5 mg, 500 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Sciadopitysin (orb1301256)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,170.00
5 mg
¥ 1,820.00
1 ml x 10 mM (in DMSO)
¥ 2,340.00
10 mg
¥ 2,730.00
25 mg
¥ 4,680.00
50 mg
¥ 6,760.00
100 mg
¥ 9,490.00
500 mg
¥ 18,980.00
DispatchUsually dispatched within 3-5 working days
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