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Sclareol

SKU: orb1304615

Description

Sclareol is a labdane diterpene isolated from Salvia sclarea with demonstrated growth-inhibitory and cytotoxic effects against various human cancer cell lines in vitro. It serves as a valuable research tool for studying natural product-derived anticancer mechanisms in cell-based assays.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number515-03-7
MW308.5
Purity99.50% (May vary between batches)
FormulaC20H36O2
SMILESC[C@]12[C@@](CC[C@@](C)(O)[C@@H]1CC[C@@](C=C)(C)O)(C(C)(C)CCC2)[H]
TargetApoptosis
SolubilityH2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (16.21 mM);Ethanol:23 mg/mL (74.55 mM);DMSO:250 mg/mL (810.37 mM)

Bioactivity

In Vivo
Sclareol inhibits DNA synthesis in human breast cancer cell lines, inducing apoptosis that does not depend on p53 and causing cell cycle arrest at the G(0/1) phase. Intratumoral injection of Sclareol decreases in-vivo growth of breast cancer tumors. It demonstrates growth inhibition and cytotoxicity across various human cancer cell lines. Additionally, Sclareol exhibits anti-inflammatory activity in lipopolysaccharide-stimulated macrophages by reducing the expression of inflammatory cytokines and increasing the activity of antioxidant enzymes.
In Vitro
Ingestion of Sclareol in rats demonstrates an LD50 greater than 5 g/kg.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Salvia sclarea, Sclareol, P-388, leukemia, Inhibitor, human epidermal?carcinoma?, inhibit, cell, Apoptosis

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

Sclareol (orb1304615)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
¥ 910.00
25 mg
¥ 1,040.00
50 mg
¥ 1,170.00
100 mg
¥ 1,300.00
500 mg
¥ 2,210.00
DispatchUsually dispatched within 3-5 working days
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