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Scoulerine

SKU: orb1297212

Description

Scoulerine is a small molecule BACE1 inhibitor and a potent antimitotic agent. It suppresses cancer cell proliferation by arresting the cell cycle and inducing apoptosis, making it a candidate for research in oncology and neurodegenerative disease models, both in vitro and in vivo.

Research Area

Cell Biology, Infectious Disease & Virology, Neuroscience, Signal Transduction

Images & Validation

Key Properties

CAS Number6451-73-6
MW327.37
Purity99.22% (May vary between batches)
FormulaC19H21NO4
SMILES[H][C@@]12Cc3ccc(OC)c(O)c3CN1CCc1cc(OC)c(O)cc21
TargetParasite|||Beta-Secretase|||BACE|||Apoptosis

Bioactivity

In Vitro
Forty-six isoquinoline alkaloids, of eleven structural types isolated in our laboratory, have been evaluated for their cytotoxicity against two cancer cell lines (Caco-2 and Hep-G2 cancer cells), as well as against normal human lung fibroblast cells. Only Scoulerine, aromoline, berbamine and parfumidine showed significant cytotoxic effects, but only Scoulerine was active against both Caco-2 and Hep-G2 cells (IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively). Unfortunately, except for parfumidine, the other active alkaloids were also cytotoxic to the normal human lung fibroblast cells

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Antifection, Apoptosis, BACE1, BACE, BetaSecretase, Beta-secretase, bSecretase, b-Secretase, cancer, cycle, division, Discretamine, cells, P. falciparum, mitotic, microtubule, Microtubule/Tubulin, Inhibitor, inhibit, leukemic, Scoulerine, proliferation, β-Secretase, βSecretase

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 90.00
5 mg
$ 210.00
10 mg
$ 330.00
25 mg
$ 530.00
DispatchUsually dispatched within 5-10 working days
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