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SD-208

SKU: orb1306459

Description

SD-208

Research Area

Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number627536-09-8
MW352.75
Purity≥95% (May vary between batches)
FormulaC17H10ClFN6
SMILESFc1ccc(Cl)cc1-c1nc(Nc2ccncc2)c2nccnc2n1
TargetTGF-beta/Smad
SolubilityDMSO:7.1 mg/mL (20.13 mM)

Bioactivity

Target IC50
TGFβRI:48 nM
In Vivo
In vitro, SD-208 inhibits TGF-β-induced receptor-associated Smads, Smad2/3 phosphorylation, and stimulates differentiation, migration, and invasion from epithelial to mesenchymal cells into the basal membrane. Additionally, SD-208 blocks the protective effects of TGF-β on the migration and proliferation of neointimal smooth muscle-like cells. In both mouse SMA-560 and human SMA-560 glioma cells, SD-208 suppresses cell growth, constitutive and TGF-β-induced migration and infiltration, and enhances immunogenicity.
In Vitro
SD-208 (1 mg/mL, p.o.) significantly prolonged the median survival rate of mice loaded with SMA-560 glioma. In syngeneic 129S1 mice, SD-208 (60 mg/kg, p.o.) inhibited the growth of primary R3T tumors and reduced the number and size of lung metastases. Additionally, in a murine aortic allograft model, SD-208 effectively reduced the formation of intimal hyperplasia associated with transplant arteriosclerosis.
Cell Research
Glioma cells are cultured in the absence or presence of SD-208 (1 μM) for 48 hours. The cells are pulsed for the last 24 hours with [methyl-3H]thymidine (0.5 μCi) and harvested, and incorporated radioactivity is determined in a liquid scintillation counter.(Only for Reference)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, inhibit, ALK5 Inhibitor V, SD208, SD-208, SD 208, Smad, Transforming growth factor beta receptors, TGFbeta/Smad, TGF-beta, TGFβ, TGF-β Receptor, TGF-βRI (ALK5), TGF-β/Smad, TGF-b/Smad, TGFb, TGFbeta

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  • SD-208 [orb1224418]

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    627536-09-8

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    C17H10ClFN6

    1 g, 500 mg, 200 mg, 50 mg, 2 mg, 10 mg, 5 mg, 100 mg, 25 mg
Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

SD-208 (orb1306459)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
¥ 910.00
5 mg
¥ 1,170.00
1 ml x 10 mM (in DMSO)
¥ 1,300.00
10 mg
¥ 1,430.00
25 mg
¥ 2,470.00
50 mg
¥ 3,510.00
100 mg
¥ 5,200.00
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