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SEN 12333

SKU: orb1217550

Description

α7 nicotinic acetylcholine receptor (nAChR) agonist.

Images & Validation

Key Properties

CAS Number874450-44-9
MW339.43
Purity>98% (HPLC)
FormulaC20H25N3O2
SMILESO=C(CCCCN1CCOCC1)Nc(cc1)ccc1-c1cnccc1
TargetAChR
SolubilityDMSO:<33.94mg/ml

Bioactivity

In Vivo
SEN12333 (intraperitoneal injection; 3 mg/kg) improves episodic memory in a novel object recognition task in rats in conditions of spontaneous forgetting as well as cognitive disruptions induced via glutamatergic or cholinergic mechanisms. SEN12333 also prevents a scopolamine-induced deficit in a passive avoidance task.
In Vitro
In whole-cell patch-clamp recordings, SEN12333 activates peak currents and maximal total charges similar to acetylcholine (EC50 = 12 μM). SEN12333 displays functional antagonism at histamine H3 receptors (IC50 = 103 nM) and weak agonist activity at human ganglionic α3 nAChRs (IC50 = 8.5 μM).

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • SEN12333 [orb1305657]

    99.94% (May vary between batches)

    874450-44-9

    339.43

    C20H25N3O2

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO)
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Protocol Information

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2 mg
$ 80.00
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100 mg
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