Setiptiline maleate

SKU: orb1708531

Description

Setiptiline maleate is the salt form of Setiptiline, a multi-target agent acting as a norepinephrine reuptake inhibitor, α2-adrenergic antagonist, H1 inverse agonist, and 5-HT antagonist. It is used in research for investigating antidepressant mechanisms and has been studied in both in vivo animal models and in vitro receptor binding assays.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	85650-57-3
MW	377.43
Purity	99.94%
Formula	C₂₃H₂₃NO₄
SMILES	C(=C\C(O)=O)\C(O)=O.CN1CC2=C(C=3C(CC=4C2=CC=CC4)=CC=CC3)CC1
Target	5-HT Receptor,Norepinephrine,Adrenergic Receptor,Histamine Receptor
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.74 mM);DMSO:80 mg/mL (211.96 mM)

Bioactivity

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In Vivo

Setiptiline maleate mildly increased spontaneous motor activity and ambulation in rats (open field test), and enhanced the locomotor stimulation induced by methamphetamine. Setiptiline maleate significantly reduced immobility time in the forced swim test in rats, indicating antidepressant-like properties. Setiptiline maleate inhibited haloperidol-induced catalepsy, physostigmine-induced yawning, 5-HTP + Ro4-4602-induced body shaking and head twitch, and morphine withdrawal-induced body shaking.

Storage & Handling

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Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ORG8282, ORG-8282, MO 8282, MO8282, MO-8282, MOD20, MOD-20, Setiptiline Maleate

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Compound Identifiers

PubChem CID

5282470 ↗

Key Properties

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No computed properties available.

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