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Setmelanotide

SKU: orb1941004

Description

Setmelanotide (RM-493, BIM-22493, IRC-022493) is a peptide, non-selective melanocortin receptor agonist with binding Ki of 3.9/10/2.1 for hMC1R/hMC3R/hMC4R, respectively; exhibits weak activity at MC5R (EC50>1 uM) and inactive at the mouse MC2R (EC50>10 uM); acutely improves glucose homeostasis, causes weight loss and improves hyperinsulinemia and fatty liver in diet induced obese mice.Obesity Phase 3 Clinical.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number920014-72-8
MW1117.309
Purity>98% (HPLC)
FormulaC49H68N18O9S2
SMILESCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)C(CCCN=C(N)N)NC(=O)C)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CN=CN5
TargetMelanocortin Receptor
SolubilityDMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

RM-493 | BIM-22493 | IRC-022493

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Quality Guarantee

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Protocol Information

Available Sizes

Select a size below

200 mg
500 mg
5 mg
$ 370.00
10 mg
$ 570.00
25 mg
$ 1,020.00
50 mg
$ 1,630.00
100 mg
$ 2,220.00