Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

SEW2871

SKU: orb1225498

Description

Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice.

Images & Validation

Key Properties

CAS Number256414-75-2
MW440.36
Purity>98% (HPLC)
FormulaC20H10F6N2OS
SMILESFC(C1=CC(C2=NOC(C3=CC(C4=CC=CC=C4)=C(C(F)(F)F)S3)=N2)=CC=C1)(F)F
TargetS1P Receptor
SolubilityDMSO > 10 mM

Bioactivity

In Vivo
Animal model: IL-10–/– (interleukin (IL)-10 gene-deficient) mice, a murine model of Crohn's disease (CD). Dosage: 20 mg/kg. Administration: Gavage, once daily for 2 weeks. Result: Ameliorated established colitis in IL-10–/– mice, associated with a reduction of serum amyloid A concentration, a decreased colon MPO concentration, a depletion of the peripheral CD4+CD45+ T cells and a reduction of the homing of T cells into colon LP. Suppressed typical cytokines of T helper type 1 (Th1) and Th17 cells and p-STAT-3 expression, and significantly decreased TNF-α, IFN-γ, IL-1β and IL-17A mRNA levels.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SEW2871 | SEW2871 | SEW2871.

Similar Products

  • SEW​2871 [orb1306226]

    99.62% (May vary between batches)

    256414-75-2

    440.36

    C20H10F6N2OS

    1 mg, 5 mg, 10 mg, 2 mg, 50 mg, 25 mg, 1 ml x 10 mM (in DMSO)
  • Fingolimod hydrochloride [orb1226037]

    >98% (HPLC)

    162359-56-0

    343.9318

    C19H34ClNO2

    200 mg, 50 mg, 100 mg, 500 mg, 1 g
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Protocol Information

Available Sizes

Select a size below

100 mg
200 mg
500 mg
2 mg
$ 140.00
5 mg
$ 250.00
10 mg
$ 420.00
25 mg
$ 690.00
50 mg
$ 1,000.00