SIB-1553A hydrochloride

SKU: orb1706636

Description

SIB-1553A

Research Area

Neuroscience

Images & Validation

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Key Properties

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CAS Number	191611-89-9
MW	273.82
Purity	99.73%
Formula	C₁₃H₂₀ClNOS
SMILES	Cl.CN1CCCC1CCSc1ccc(O)cc1
Target	AChR
Solubility	H2O:20 mg/mL (73.04 mM)

Bioactivity

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In Vivo	In Male Sprague-Dawley rats (200-250 g), SIB-1553A hydrochloride (1, 2, 4, 10, 20, and 40 mg/kg; s.c) induced hippocampal ACh release.
In Vitro	In calcium flux assays, compared to nicotine, SIB-1553A hydrochloride (0.1-5 μM) exhibits higher selectivity in both potency and efficacy towards β4 subunits containing recombinant hnAChRs (α2β4, α3beta4, and α4β4) over β2 subunits containing nAChRs (α4β2 and α3beta2). Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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SIB-1553A, SIB1553A, SIB 1553A, nAChR, AChR

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Compound Identifiers

PubChem CID

9881989 ↗

Key Properties

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No computed properties available.

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