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Siponimod

SKU: orb1300798

Description

Siponimod

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Siponimod

Key Properties

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CAS Number1230487-00-9
MW516.59
Purity97.08% (May vary between batches)
FormulaC29H35F3N2O3
SMILESC(F)(F)(F)C1=C(C=CC(CO/N=C(\C)/C2=CC(CC)=C(CN3CC(C(O)=O)C3)C=C2)=C1)C4CCCCC4
TargetLPL Receptor,S1P Receptor
SolubilityEthanol:41 mg/mL (79.37 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.94 mM);DMSO:29.71 mg/mL (57.51 mM)

Bioactivity

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Target IC50
S1P5 receptor:0.98 nM (EC50)|S1P2 receptor:>10000 nM (EC50)|S1P4 receptor:750 nM (EC50)|S1P1 receptor:0.39 nM (EC50)|S1P3 receptor:>1000 nM (EC50)
In Vivo
BAF312 is a potent and selective S1P receptor agonist. Its EC50s for S1P1 and S1P5 receptors were 0.39 nM and 0.98 nM, respectively, and it was more than 1000-fold more potent than S1P2, S1P3, and S1P4 receptors at S1P1 and S1P5 receptors.
In Vitro
BAF312 is a potent and selective S1P receptor agonist. Its EC50s for S1P1 and S1P5 receptors were 0.39 nM and 0.98 nM, respectively, and it was more than 1000-fold more potent than S1P2, S1P3, and S1P4 receptors at S1P1 and S1P5 receptors.
Cell Research
Agonist-mediated internalization of S1P1 receptors in CHO cells analysed by flow cytometry Myc-tag hS1P1 cells are incubated for 1 h with agonist at 37°C in standard culture medium followed by a PBS wash. An aliquot is kept on ice for 3 h, while another aliquot is left for 3 (or 12) h in culture medium (no agonist) at 37°C. The cells are then incubated either with 4 μg/mL monoclonal mouse anti C-myc IgG1 antibody or with isotype control mouse IgG1 for 60 min at 4°C, followed by an incubation with 1 μg/mL of Alexa488-labelled goat anti-mouse secondary conjugates. The cells are subjected to flow cytometry measurements using 10000 viable cells per sample.(Only for Reference)

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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inhibit, multiple sclerosis, inflammation, LPL Receptor, LPL, LPLReceptor, neurodegeneration, Lysophospholipid Receptor, lymphocytes, Inhibitor, BAF 312, BAF312, BAF-312, Siponimod, S1PReceptor, S1P receptor, S1P Receptor, S1P1, S1P1 agonist, S1P2, S1P3, S1P4, S1P5, progressive

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
44599207 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

Select a size below

2 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 100.00
5 mg
$ 100.00
10 mg
$ 120.00
25 mg
$ 170.00
50 mg
$ 280.00
100 mg
$ 370.00
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