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SIRT5 inhibitor 4

SKU: orb1688578

Description

Compound 11 (SIRT5 inhibitor 4) is a selective, dose-dependent inhibitor of SIRT5 with an IC50 of 26.4 µM, showing no activity against SIRT1-3 at 400 µM. It is a valuable chemical probe for investigating SIRT5's role in cancer metabolism and tumorigenesis in cellular and biochemical studies.

Research Area

Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number708992-34-1
MW369.39
FormulaC18H15N3O4S
SMILESN(C1=NC(=CS1)C2=CC=C(NC(C)=O)C=C2)C3=CC(O)=C(C(O)=O)C=C3
TargetOthers

Bioactivity

Target IC50
SIRT5:26.4 μM
In Vitro
SIRT5 inhibitor 4 was identified as a selective SIRT5 inhibitor (IC₅₀ = 26.4 ± 0.8 μM) with no inhibition on SIRT1–3.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information