SK1-I hydrochloride

SKU: orb1689232

Description

SK1-I hydrochloride is the salt form of the selective sphingosine kinase 1 (SphK1) inhibitor SK1-I (BML-258). This compound exhibits anti-leukemic activity by inhibiting tumor cell growth and inducing apoptosis in vitro, and has been utilized in research exploring cancer therapeutics and sphingolipid signaling pathways.

Research Area

Pharmacology & Drug Discovery

Images & Validation

−

Key Properties

−

CAS Number	2366222-05-9
MW	313.86
Purity	99.80%
Formula	C₁₇H₂₈ClNO₂
SMILES	C(=C/[C@@H]([C@@H](CO)NC)O)\C1=CC=C(CCCCC)C=C1.Cl
Target	S1P Receptor

Bioactivity

−

In Vivo

In the C57BL/6 male mouse model, pretreatment with SK1-I hydrochloride (intraperitoneal injection, 75mg/kg, a single dose administered 24 hours before baseline mean arterial pressure measurement) showed a significant hypotensive effect, significantly reducing the baseline mean arterial pressure (MAP) .

In Vitro

The effect of SK1-I hydrochloride on cancer cell growth, survival, and apoptosis is closely related to the TP53 status. Treatment of HCT116 cells with a defective TP53 mutation and normal HCT116 cells with SK1-I hydrochloride (0-10μM) for 24 hours revealed that the growth and survival rate of normal HCT116 cells decreased significantly. In protein blot analysis, after treating both cell types with SK1-I hydrochloride (0-20μM) for 12 hours, it was found that CASP3 cleavage was increased in normal HCT116 cells, making them more prone to apoptosis .

Storage & Handling

−

Storage	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

BML258 hydrochloride, BML-258 hydrochloride

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

49793059 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols