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SKP-451

SKU: orb3028802

Description

SKP-451 is an ATP-sensitive potassium (K+) channel agonist. It activates ATP-sensitive K+ channels, promoting the efflux of K+, leading to membrane hyperpolarization and inhibiting Ca2+ influx, which results in the relaxation of vascular smooth muscle. SKP-451 relaxes canine coronary arteries, rabbit basilar arteries, and vertebral arteries. Additionally, SKP-451 lowers mean arterial blood pressure in conscious spontaneously hypertensive rats (SHR). It holds potential for cardiovascular disease research.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number181137-41-7
MW346.335
FormulaC17H18N2O6
SMILESN(=O)(=O)C=1C=C2C(=C[C@](C)(OC2=CC1)[C@@H]3OCCO3)N4C(=O)CCC4
TargetPotassium Channel

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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SKP-451 (orb3028802)

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