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SMBA1

SKU: orb1737453

Description

SMBA1 is a potent small molecule Bax agonist that induces apoptosis and cell cycle arrest in cancer cells, such as malignant gliomas. Its utility extends to research on triple-negative breast cancer, with studies demonstrating its activity in both in vitro cellular assays and in vivo tumor models.

Research Area

Cell Biology

Images & Validation

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SMBA1

Key Properties

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CAS Number906440-37-7
MW315.32
Purity99.20% (May vary between batches)
FormulaC20H13NO3
SMILESO=[N+]([O-])C1=CC2=C(C3=CC=CC=C3C2=CC4=C(O)C=CC=C4)C=C1
TargetBcl-2 Family

Bioactivity

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Target IC50
Bax:43.3 nM (Ki)
In Vivo
SMBA1 (2, 10, 40, 60 mg/kg; intraperitoneal injection; once daily for 10 days) exhibited antitumor activity in mice.
In Vitro
SMBA1 exhibited Bax agonist activity by inhibiting the phosphorylation of S184, promoting the insertion of Bax into the mitochondrial membrane and the formation of Bax oligomers, and thereby inducing conformational changes in Bax. SMBA1 (0, 0.1, 1, 5, 10 µM; 24 hr) potentiated Bax expression in a dose-dependent manner in A549 cells.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Bax, SMBA1, SMBA-1, SMBA 1
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
349156 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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1 mg
$ 140.00
5 mg
$ 280.00
10 mg
$ 390.00
25 mg
$ 610.00
50 mg
$ 840.00
100 mg
$ 1,130.00
500 mg
$ 2,230.00
DispatchUsually dispatched within 6-8 weeks
Bulk Enquiry
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Email

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Distributors

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