Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

SMER18

SKU: orb1706620

Description

SMER18 is a small molecule autophagy inducer that functions independently of mTOR, thereby enhancing the effects of rapamycin. It serves as a valuable research tool for investigating autophagy mechanisms and their implications in neurodegenerative disease models, both in vitro and in vivo.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number944153-47-3
MW287.74
Purity97.27% (May vary between batches)
FormulaC16H14ClNO2
SMILESC\C(Nc1cccc(O)c1)=C\C(=O)c1ccc(Cl)cc1
TargetAutophagy
SolubilityDMSO:80 mg/mL (278.03 mM)

Bioactivity

In Vitro
SMER18 is a small molecule enhancer of rapamycin that functions as an mTOR-independent autophagy inducer, capable of enhancing the clearance of autophagy substrates such as mutant htt (related to Huntington's disease) and A53T α-synuclein (associated with familial Parkinson's disease).

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Autophagy, SMER 18, SMER18, SMER-18
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 180.00
5 mg
$ 390.00
1 ml x 10 mM (in DMSO)
$ 420.00
10 mg
$ 540.00
25 mg
$ 1,010.00
50 mg
$ 1,530.00
100 mg
$ 2,020.00
DispatchUsually dispatched within 5-10 working days
Bulk Enquiry