α-Solanine

SKU: orb1684775

Description

α-Solanine is a potato-derived alkaloid with demonstrated anticancer properties, including the inhibition of glioma cell proliferation and migration and the induction of apoptosis. Its mechanism involves attenuating chondrocyte death through NF-κB pathway inhibition, making it a compound of interest for in vitro oncology and inflammation research.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Protein Biochemistry, Signal Transduction

Images & Validation

−

Key Properties

−

CAS Number	20562-02-1
MW	868.06
Purity	99.37%
Formula	C₄₅H₇₃NO₁₅
SMILES	C[C@@H]1[C@H]2CC[C@H](C)CN2[C@H]2C[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]3(C)[C@@H]12)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]1O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O
Target	Autophagy,MMP,mTOR,COX,NO Synthase,Akt,NF-κB,Apoptosis
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.15 mM);DMSO:30 mg/mL (34.56 mM)

Bioactivity

−

In Vivo

METHODS: 1 μl/g of α-solanine was injected into the peritoneal cavity of each mouse for two weeks. The body weight of the mice and the size of their tumors were measured daily. RESULTS: α-solanine inhibited the growth of PANC-1 tumor xenografts, reducing tumor volume by 61% (P<0.05).

In Vitro

METHODS: α-solanine (3, 6, 9, 12 μg/μl) was used to treat PANC-1, sw1990 and MIA PaCa-2 cells for 24 h or 48 h, and the viability of cells was observed. RESULTS: After treatment with α-solanine (12 μg/μl), the cell viability was significantly decreased. At α-solanine concentrations of 3, 6, and 9 μg/μl, and treatment time of 24 h and 48 h, α-solanine did not cause cytotoxicity in the cells of each cell line. α-Solanine (3, 6 and 9 μg/μl) significantly reduced the mRNA and protein expression of VEGF in PANC-1 cells in a dose-dependent manner, while α-solanine inhibited angiogenesis by inhibiting VEGF expression.

Storage & Handling

−

Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

alpha-Solanine, Apoptosis, a-Solanine, Akt, MMP, NF-κB, NFκB, NFkB, NF-kB, α Solanine, αSolanine, α-Solanine, PI3K

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

9549171 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

α-Solanine (orb1684775)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

CAS Number:	20562-02-1
MW:	868.06
Formula:	C₄₅H₇₃NO₁₅

α-Solanine

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

α-Solanine (Standard) [orb3139335]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

α-Solanine (orb1684775)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors