Sparfosic acid trisodium

SKU: orb1708476

Description

Sparfosic acid trisodium is a dual inhibitor of CAD and aspartate transcarbamoylase, key enzymes in de novo pyrimidine synthesis, exhibiting antitumor properties. It has been utilized in research to study nucleotide metabolism and evaluate potential anticancer effects in both cellular and animal models.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	70962-66-2
MW	277.1
Formula	C₆H₉NNaO₈P
SMILES	O=P([O-])(O)CC(N[C@H](C(O)=O)CC(O)=O)=O.[Na+]
Target	Apoptosis
Solubility	H2O:200 mg/mL (721.76 mM);DMSO:160 mg/mL (577.41 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (18.04 mM)

Bioactivity

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In Vivo

Method: Sparfosic acid trisodium was administered intraperitoneally at a dose of 490 mg/kg on days 1, 5, and 9 to tumor-bearing mice implanted with either B16 melanoma or Lewis lung carcinoma, to evaluate its antitumor efficacy. Result: In the B16 melanoma model, Sparfosic acid trisodium extended mouse survival by 77%–86% compared to controls. In the Lewis lung carcinoma model, the compound showed high sensitivity; subcutaneous administration on days 1, 5, and 9 Resulted in a 50% cure rate in tumor-bearing mice.

Storage & Handling

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Storage	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Sparfosic acid, Sparfosic acid trisodium

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Compound Identifiers

PubChem CID

154728861 ↗

Key Properties

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No computed properties available.

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