Cart summary

You have no items in your shopping cart.

SR-717

SKU: orb1298740

Description

SR-717 is a non-nucleoside STING agonist analog of cGAMP that stabilizes the protein in a closed, active conformation. It has demonstrated antitumor efficacy in preclinical models by enhancing immune cell activation and antigen cross-presentation in both cellular and animal studies.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number2375421-09-1
MW351.19
Purity99.98%
FormulaC15H8F2LiN5O3
SMILES[Li+].[O-]C(=O)c1cc(F)c(F)cc1NC(=O)c1ccc(nn1)-n1ccnc1
TargetSTING
SolubilityDMSO:20 mg/mL (56.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (7.12 mM)

Bioactivity

Target IC50
ISG-THP1 cGAS KO (cGAS KO) cells:2.2 μM (EC50)|ISG-THP1 (WT) cells:2.1 μM (EC50)|STING (B16 cells):7.8 µM
In Vivo
METHODS: To test the antitumor activity in vivo, SR-717 (30 mg/kg) was injected intraperitoneally into WT or Stinggt/gt C57BL/6 mice bearing mouse cutaneous melanoma tumor B16.F10 once daily for seven days. RESULTS: SR-717 inhibited tumor growth as well as prolonged the survival time of mice with rhabdomyosarcoma. The antitumor effect of SR-717 showed an enforced dependence on STING expression, and a lack of activity was observed in Stinggt/gt mice. METHODS: To assay antitumor activity in vivo, SR-717 (10 mg/kg) was administered intravenously three times every two days to C57BL/6 mice harboring mouse cutaneous melanin tumor B16.F10. RESULTS: SR-717 has anti-tumor activity in vivo and prolongs survival.
In Vitro
METHODS: Macrophage THP1 were treated with SR-717 (3.6 µM) for 10 min-6 h. The expression levels of target proteins were detected using Western Blot. RESULTS: SR-717 activates p-STING, and its downstream p-TBK1, p-IRF3, p-p65, p-STAT1 and p-STAT3. METHODS: Primary human peripheral blood mononuclear cell PBMCs were treated with SR-717 (10 µM) for 2-6 h. Gene expression levels were detected using RT-qPCR. RESULTS: SR-717 stimulated the activation of IFNB1, CXCL10 and IL6.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SR 717, SR717, SR-717, STING, Stimulator of Interferon Genes, TMEM173, THP1, inhibit, ISG-THP1, MPYS, PD-L1, MITA, mimetic, immunity, Inhibitor, ERIS, cGAMP, antitumor

Similar Products

  • SR-717 free acid [orb1690959]

    2375420-34-9

    345.266

    C15H9F2N5O3

    5 mg, 25 mg
  • SR-717 [orb1219802]

    >98% (HPLC)

    2375421-09-1

    351.2

    C15H8F2LiN5O3

    1 g, 500 mg, 200 mg, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

SR-717 (orb1298740)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,040.00
2 mg
¥ 1,170.00
5 mg
¥ 1,560.00
10 mg
¥ 2,210.00
1 ml x 10 mM (in DMSO)
¥ 2,340.00
25 mg
¥ 3,900.00
50 mg
¥ 5,980.00
100 mg
¥ 9,880.00
200 mg
¥ 12,610.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry