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SR0987

SKU: orb1221568

Description

SR-0987 is a T cell-specific RORγ (RORγt) agonist. SR-0987 induces IL-17 expression and decreases PD-1 expression in T cells in vitro.

Images & Validation

Key Properties

CAS Number303126-97-8
MW397.7
Purity>98% (HPLC)
FormulaC16H10ClF6NO2
SMILESO=C(Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c2ccccc2Cl
TargetROR
SolubilityDMSO : ≥ 150 mg/mL 377.17 mM H2O : < 0.1 mg/mL

Bioactivity

In Vitro
SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC50 of ~800 nM. SR0987 treatment results in a statistically significant reduction of the surface expression of PD-1 whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trend towards increased IL17 production.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SR-0987 | SR0987 | SR 0987

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    99.43% (May vary between batches)

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    C16H10ClF6NO2

    10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 2 mg, 5 mg
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Protocol Information

SR0987 (orb1221568)

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Available Sizes

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200 mg
500 mg
5 mg
¥ 1,430.00
10 mg
¥ 2,340.00
25 mg
¥ 4,160.00
50 mg
¥ 7,020.00
100 mg
¥ 10,140.00