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SR17018

SKU: orb1302885
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Description

SR17018 is a potent and selective mu-opioid receptor (MOR) agonist, demonstrating an EC50 of 97 nM in GTPγS binding assays. This small molecule is a valuable research tool for studying MOR signaling and pharmacology in both in vitro and in vivo models of pain and addiction.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2134602-45-0
MW410.72
Purity99.89%
FormulaC19H18Cl3N3O
SMILESClc1ccc(CN2CCC(CC2)n2c3cc(Cl)c(Cl)cc3[nH]c2=O)cc1
TargetOpioid Receptor
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.43 mM);DMSO:4.11 mg/mL (10.01 mM)

Bioactivity

Target IC50
μ opioid receptor:NA
In Vitro
SR17018 acts as an agonist at the mu-opioid receptor (MOR), exhibiting binding affinity with GTPγS, demonstrated by an EC50 value of 97 nM. It does not significantly induce βarrestin2 recruitment to the MOR at concentrations below 10 μM, suggesting its mechanism of action primarily involves signaling through G proteins rather than βarrestin2 pathways.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, Opioid Receptor, OpioidReceptor, inhibit, SR17018, SR-17018, SR 17018, μ-opioid receptor

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Key Properties

No computed properties available.

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SR17018 (orb1302885)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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5 mg
¥ 5,590.00
10 mg
¥ 7,150.00
50 mg
¥ 19,370.00
100 mg
¥ 28,340.00
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