Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

SR9011

SKU: orb1303894

Description

SR9011 is a potent and selective agonist of the nuclear receptors REV-ERBα and REV-ERBβ, with respective IC50 values of 790 nM and 560 nM. This research compound is widely used in vitro and in vivo to study circadian biology, metabolism, and inflammatory processes.

Research Area

Cell Biology, Metabolism Research

Images & Validation

Key Properties

CAS Number1379686-29-9
MW479.04
Purity99.65% (May vary between batches)
FormulaC23H31ClN4O3S
SMILESCCCCCNC(=O)N1CCC(CN(Cc2ccc(s2)[N+]([O-])=O)Cc2ccc(Cl)cc2)C1
TargetREV-ERB,Autophagy
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.18 mM);DMSO:50 mg/mL (104.38 mM)

Bioactivity

Target IC50
Rev-Erbα:560 nM|Rev-Erb:790 nM
In Vivo
SR9011 inhibits the activity of the SCN clock, with reversible inhibition of circadian oscillations in SCN explants cultured from the Per2: Luc reporter mouse.
In Vitro
SR9011 and SR9009 effectively inhibits transcription in a cotransfection assay using full-length REV-ERBα along with a luciferase reporter driven by the Bmal1 promoter (SR9011 IC50: 620 nM). SR9011 suppresses the expression of BMAL1 mRNA in HepG2 cells in a REV-ERBα/β-dependent manner.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Rev-ErbBα, Rev-ErbBβ, SR 9011, SR9011, SR-9011, Inhibitor, inhibit

Similar Products

  • SR9011 hydrochloride [orb1691284]

    2070014-94-5

    515.49

    C23H32Cl2N4O3S

    2 mg
  • SR9011 [orb1223326]

    >98% (HPLC)

    1379686-29-9

    479.04

    C23H31ClN4O3S

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 g, 500 mg, 200 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

SR9011 (orb1303894)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,300.00
2 mg
¥ 1,560.00
5 mg
¥ 2,600.00
1 ml x 10 mM (in DMSO)
¥ 2,730.00
10 mg
¥ 4,160.00
25 mg
¥ 6,630.00
50 mg
¥ 9,490.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry