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SR9243

SKU: orb1307414

Description

SR9243 is an LXR inverse agonist that promotes LXR-corepressor binding. It exhibits anticancer properties by selectively disrupting cancer cell metabolism, specifically inhibiting de novo lipogenesis and the Warburg effect, as demonstrated in both in vitro and in vivo studies.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1613028-81-1
MW626.62
Purity98.75%
FormulaC31H32BrNO4S2
SMILESCc1cc(C)c(c(C)c1)S(=O)(=O)N(CCc1cccc(Br)c1)Cc1ccc(cc1)-c1cccc(c1)S(C)(=O)=O
TargetLiver X Receptor
SolubilityDMSO:20 mg/mL (31.92 mM);10% DMSO+90% Corn Oil:2 mg/mL (3.19 mM)

Bioactivity

In Vivo
In Ob/Ob mice fed a high-fat diet, SR9243 (60 mg/kg, i.p.) inhibits LXR-dependent lipogenic enzyme gene expression and tumor growth.
In Vitro
In HEK293 cells expressing LXRs, SR9243 inhibits LXR activation by enhancing LXR-corepressor recruitment. In a variety of cancer cell types, SR9243 reduces cancer cell viability, induces apoptotic cell death, and sensitizes cancer cells to chemotherapeutic treatments.
Cell Research
Cells are cultured in 96 well plates and treated with designated amounts of SR9243 for 96 hr in media containing 1% FBS and antibiotics. Cell-viability is assessed using the Cell-titre 96 kit according to the manufacturer's guidelines. Cell culture media is supplemented with oleate, stearate and palmitate dissolved in methanol to a concentration of 25 mM. 25 mM stocks are then diluted 10 fold in PBS containing 0.9% BSA. Lipid stocks (100X) are stored at 20° until needed.(Only for Reference)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, Liver X receptor, Liver X Receptor, LiverXReceptor, LXR, Inhibitor, SR 9243, SR9243, SR-9243

Similar Products

  • SR9243 [orb1226058]

    >98%(HPLC)

    1613028-81-1

    626.6

    C31H32BrNO4S2

    1 g, 500 mg, 5 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg
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Key Properties

No computed properties available.

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Protocol Information

SR9243 (orb1307414)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
¥ 1,040.00
5 mg
¥ 1,300.00
1 ml x 10 mM (in DMSO)
¥ 1,430.00
10 mg
¥ 1,560.00
25 mg
¥ 2,210.00
50 mg
¥ 3,120.00
100 mg
¥ 4,680.00
200 mg
¥ 7,280.00
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