SRI-011381 hydrochloride

SKU: orb1302064

Description

SRI-011381 hydrochloride is a novel small molecule agonist of the TGF-β signaling pathway. It is used in research for Alzheimer's disease, showing potential in both in vitro neuronal models and in vivo preclinical studies to modulate neuroprotective pathways.

Research Area

Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	2070014-88-7
MW	365.94
Purity	98.00% (May vary between batches)
Formula	C₂₀H₃₂ClN₃O
SMILES	Cl.O=C(NC1CCCCC1)N(CC1CCNCC1)Cc1ccccc1
Target	TGF-beta/Smad
Solubility	H2O:76.92 mg/mL (210.2 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.47 mM);DMSO:34.29 mg/mL (93.7 mM)

Bioactivity

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In Vivo

SRI-011381 protects mice against kainic acid-induced excitotoxicity and neurodegeneration. SRI-011381 (30 mg/kg, dissolved in DMSO) is injected (i.p.) into the SBE-luc mice. SRI-011381 is rapidly absorbed after oral administration to FBV mice with an oral bioavailability of approximately 50%. SRI-011381 by oral gavage of 10, 30, and 75 mg/kg for 14 days resulted in significant changes in hematological endpoints, most notably reductions in red blood cells, hematocrit and hemoglobin. SRI-011381 reduces neurodegeneratio in APP751Lon, Swetransgenic mice.

In Vitro

SRI-11381 is neuroprotective. SRI-011381 promote fibrillar Aβ clearance by macrophages, as demonstrated by the dose-dependent decreases of Aβ in the conditioned medium derived from compound-treated macrophages.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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collagen-1, NALP3, neuroprotective, multiple, inhibit, Inhibitor, sclerosis, Smad, SRI 011381, SRI 011381 hydrochloride, SRI 011381 Hydrochloride, SRI011381, SRI-011381, SRI011381 Hydrochloride, SRI011381 hydrochloride, SRI-011381 Hydrochloride, SRI-011381 hydrochloride [1629138-41-5(free base)], α-SMA, Transforming growth factor beta, TGFbeta/Smad, TGF-beta/Smad, TGFbeta, TGF-beta, TGF-β/Smad, TGF-β, TGFβ, TGFb, TGF-b/Smad

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Compound Identifiers

PubChem CID

122198132 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

Purity:	>98% (HPLC)
CAS Number:	2070014-88-7
MW:	365.94
Formula:	C₂₀H₃₂ClN₃O

Purity:	> 98%
CAS Number:	1629138-41-5 (free base)
MW:	365.94
Formula:	C₂₀H₃₂ClN₃O

SRI-011381 hydrochloride

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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