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(S,R,S)-AHPC-Me hydrochloride

SKU: orb1219497

Description

(S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM. (S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.

Images & Validation

Key Properties

CAS Number1948273-03-7
MW481.05
Purity>98% (HPLC)
FormulaC23H33ClN4O3S
SMILESCl.C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(cc1)-c1scnc1C
TargetE3 Ligase Ligand
SolubilityDMSO:62 mg/mL(128.88 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

VHL ligand 2 hydrochloride,E3 ligase Ligand 1

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(S,R,S)-AHPC-Me hydrochloride (orb1219497)

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¥ 1,040.00
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¥ 1,430.00
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¥ 1,820.00
100 mg
¥ 2,470.00