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(S,R,S)-AHPC-Me

SKU: orb1299538

Description

(S,R,S)-AHPC-Me is a potent VHL ligand derived from (S,R,S)-AHPC, designed for targeted protein degradation. It effectively degrades BET proteins with a DC50 below 1 nM in resistant prostate cancer cell models and serves as a key component in the synthesis of the PROTAC degrader ARV-771 for cancer research.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1948273-02-6
MW444.59
Purity99.86% (May vary between batches)
FormulaC23H32N4O3S
SMILESC([C@H](C(C)(C)C)N)(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
TargetLigands for E3 Ligase,E3 Ligase Ligand-Linker Conjugates

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

(S,R,S)AHPCMe, (S,R,S) AHPC Me, AHPC-Me, E3 ligase Ligand 1A, Ligands for E3 Ligase, Ligand for E3 Ligase, LigandforE3Ligase, inhibit, E3 ligase-recruiting Moiety, Inhibitor, VHL ligand 2, VHL ligand2, VHL ligand-2, VHL

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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(S,R,S)-AHPC-Me (orb1299538)

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25 mg
¥ 1,040.00
50 mg
¥ 1,170.00
100 mg
¥ 2,730.00
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