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ST 271

SKU: orb1223440

Description

ST-271 is tyrphostin tyrosine kinase inhibitor. ST271 reduced intracellular Ca2+ levels and inhibited activation of phospholipase C. Elevation of intracellular Ca2+ regulates agonist-induced activation of phospholipase C and that this contributes to the inhibition of thrombin-induced formation of inositol phosphates by the tyrphostin ST271.

Images & Validation

Key Properties

CAS Number106392-48-7
MW272.34
Purity>98% (HPLC)
FormulaC16H20N2O2
SMILESCC(C)c1cc(cc(c1O)C(C)C)/C=C(\C#N)/C(=O)N
TargetPTK
SolubilityDMSO : ≥ 110 mg/mL 403.91 mM

Bioactivity

In Vitro
ST271 partially inhibits peptide phosphorylation in the membrane preparation and in permeabilized platelets. ST271 (100 μM) causes complete inhibition of formation of inositol phosphates induced by FcγRII cross-linking, but also induces a small (< 30%) but significant inhibition of the response to thrombin and U46619.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ST-271 | ST271 | ST 271

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