Stemazole

SKU: orb1699229

Description

Stemazole

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	317337-07-8
MW	267.33
Purity	98.59%
Formula	C₉H₉N₅OS₂
SMILES	S=C1OC(C2=CC=C(NC(NN)=S)C=C2)=NN1
Target	Others,Apoptosis
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.48 mM);DMSO:11 mg/mL (41.15 mM)

Bioactivity

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In Vivo

Mice were injected intraperitoneally with MPTP (20mg/kg) four times at 2-h intervals for one day to induce Parkinsonism, and then treated with stemazole (ST) (10, 30 and 50mg/kg) for 7 days. Our results demonstrated that ST treatment improved locomotor activity and motor coordination in MPTP mice. There was also a significant increase in TH-positive cells (∼24%, P<0.01) and DAT levels (∼26%, P<0.01) in MPTP mice treated with ST (50mg/kg) compared with the vehicle group. DA and its metabolite levels were significantly increased with ST (50mg/kg) treatment (P<0.01, compared with the vehicle group). SOD and GSH-PX activities were elevated notably in ST treatment groups compared with the vehicle group. These results suggest that ST has neuroprotective effect on the impaired DA system, potentially through enhancement of the cell's anti-oxidative capacity.

In Vitro

Stemazole (10, 30, and 100 μM) enhanced clonal expansion from single cells in a dose-dependent fashion and clearly decreased apoptosis from 54.1% to 25.2%. Furthermore, the drug reduced apoptosis from 43.6% to 8.4% over 15 h of starvation, with 66% of astemizole-treated cells remaining viable after 2 weeks of starvation. Importantly, starved cells protected with stemazole retained the same proliferation and differentiation properties as cells in normal culture. Stemazole significantly promotes the survival of stem cells in single-cell or starvation cultures without compromising stemness and pluripotency.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Apoptosis, Stemazole

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Compound Identifiers

PubChem CID

3876544 ↗

Key Properties

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No computed properties available.

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Stemazole

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Stemazole (orb1699229)

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