sTGFBR3 antagonist 1

sTGFBR3 antagonist 1 (Compound p24) is a dual-pathway modulator that activates TGF-β signaling while suppressing NF-κB, demonstrating anti-inflammatory and neuroprotective effects in vitro, such as inhibiting LPS-induced NO release in BV2 microglia (IC50 = 0.52 µM). Its ability to enhance blood-brain barrier permeability supports its research utility in neurodegenerative disease models, including Alzheimer's.