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STL1267

SKU: orb1744166

Description

STL1267 is a brain-penetrant REV-ERB agonist that suppresses BMAL1 expression. This tool compound is utilized in circadian rhythm research and for modeling chronic inflammatory pain conditions in both in vitro and in vivo experimental systems.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1429024-58-7
MW322.75
Purity99.19%
FormulaC17H11ClN4O
SMILESClC1=NN=C2C=CC(=NN12)OC=3C=CC=CC3C=4C=CC=CC4
TargetREV-ERB
SolubilityDMSO:20 mg/mL (61.97 mM)

Bioactivity

Target IC50
REV-ERBα:0.16 µM (Ki)
In Vivo
Intraperitoneal injection of STL1267 (50 mg/kg) into C57Bl / 6 J mice showed that STL1267 successfully crossed the blood-brain barrier with a plasma half-life of ~1.6 hours.
In Vitro
STL1267 is an agonist of REV-ERB with a Ki value of 0.16 µM for Rev-erbα. The EC50 collected by STL1267 for NCoR ID1 is 0.13μM.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

STL 1267
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

STL1267 (orb1744166)

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% Tween 80 +
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Available Sizes

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1 mg
¥ 1,040.00
5 mg
¥ 1,690.00
1 ml x 10 mM (in DMSO)
¥ 1,820.00
10 mg
¥ 2,340.00
25 mg
¥ 4,290.00
50 mg
¥ 6,760.00
100 mg
¥ 10,530.00
DispatchUsually dispatched within 6-8 weeks
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