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STX-107

SKU: orb2815106

Description

STX-107 is a selective mGluR5 receptor agonist used in Fragile X Syndrome research. It facilitates the investigation of mGluR5 pathway modulation in both cellular assays and animal models, supporting studies on synaptic function and potential therapeutic mechanisms.

Research Area

Neuroscience

Images & Validation

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STX-107

Key Properties

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CAS Number935685-90-8
MW319.36
Purity99.17% (May vary between batches)
FormulaC18H10FN3S
SMILESN#CC1=CC(F)=CC(=C1)C2=NC=C(C#CC=3N=C(SC3)C)C=C2
TargetGluR

Bioactivity

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In Vivo
In Fmr1 knockout mice, intraperitoneal injection of STX-107 (10 mg/kg once daily for 7 days) significantly reduced autism-like hyperactivity and excessive exploratory behavior. The compound also partially restored deficits in social interaction and abnormal startle response, demonstrating its potential to ameliorate behavioral phenotypes in vivo.
In Vitro
Treatment of hippocampal neuron cultures with STX-107 (1 μM for 24 hours) significantly inhibited excessive mGluR5-mediated signaling and restored dendritic spine density and synaptic protein levels in FMR1-deficient mouse neurons, indicating its ability to modulate synaptic plasticity in vitro.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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STX107, STX 107
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
16662948 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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1 mg
$ 430.00
5 mg
$ 890.00
10 mg
$ 1,320.00
25 mg
$ 2,210.00
50 mg
$ 3,300.00
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