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Sulconazole

SKU: orb1300555

Description

Sulconazole mononitrate (Exelderm) is a synthetic imidazole antifungal agent. It disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis via cytochrome P-450, and may also interfere with fungal nucleic acid metabolism. This compound is used in research to study antifungal mechanisms in both in vitro and in vivo experimental models.

Research Area

Cancer Biology

Images & Validation

Key Properties

CAS Number61318-91-0
MW460.8
Purity>98%
FormulaC18H15Cl3N2S·HNO3
SMILESc1cc(ccc1CSC(Cn1ccnc1)c1c(cc(cc1)Cl)Cl)Cl.[N+](=O)(O)[O-]
TargetCytochrome/MDR
SolubilitySoluble in DMSO (up to at least 25 mg/ml)

Bioactivity

In Vivo
The efficacy and safety of sulconazole 1% cream has been demonstrated in controlled clinical studies in patients with superficial dermatophyte or yeast infections. To minimise the risk of reinfection treatment should continue for 3 weeks in Candida infections, tinea cruris, tinea corporis and pityriasis versicolor, and for 4 weeks in patients with tinea pedis.
In Vitro
Sulconazole mononitrate possesses a broad spectrum of activity in vitro against dermatophytes, yeasts and some Gram-positive bacteria at concentrations below 5 mg/L in vitro. It has been shown that against representatives of pathogenic yeasts, dermatophytes and Aspergilli, the RIF values of sulconazole are broadly similar to those of other imidazoles. The fungicidal potency of sulconazole in vitro depends on its concentration and on the growth phase of the inoculum cells. Sulconazole has also demonstrated antibacterial activity in vitro, with MIC values below 12.5 mg/L.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

1-(2-((4-Chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole nitrate

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Key Properties

No computed properties available.

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Sulconazole (orb1300555)

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% DMSO +
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% Tween 80 +
%

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50 mg
¥ 2,340.00
250 mg
¥ 3,770.00
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