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Sulfopin

SKU: orb1218294

Description

Sulfopin is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17nM. Sulfopin blocks Myc-driven tumors in vivo.

Images & Validation

Key Properties

CAS Number2451481-08-4
MW281.8
Purity>98% (HPLC)
FormulaC11H20ClNO3S
SMILESO=C(N(CC(C)(C)C)C(CC1)CS1(=O)=O)CCl
TargetPin1
SolubilityDMSO : 90 mg/mL (319.38 mM; Need ultrasonic)

Bioactivity

In Vitro
Cell Proliferation Assay Cell line: Kuramochi, MDA-MB-468, NGP, NBL-S, MDA-MB-468 cells. Concentration: 1, 2.5 μM Incubation time: 4, 6, 8 days. Result: Showed variation in antiproliferative effects across cancer cell lines Kuramochi, MDA-MB-468, NGP and NBL-S, with the most pronounced sensitivity observed in MDA-MB-468 cells.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PIN1-3

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    C11H20ClNO3S

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Protocol Information

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500 mg
200 mg
2 mg
$ 90.00
5 mg
$ 140.00
10 mg
$ 210.00
25 mg
$ 420.00
50 mg
$ 660.00
100 mg
$ 970.00