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Sumatriptan

SKU: orb1704027

Description

Sumatriptan (GR 43175 free base) is a selective 5-HT1B/1D/1F receptor agonist with oral bioavailability and blood-brain barrier penetration. It is widely used in research models of migraine and cerebrovascular function, employing both in vitro receptor binding assays and in vivo studies of neurogenic inflammation.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number103628-46-2
MW295.4
Purity99.77% (May vary between batches)
FormulaC14H21N3O2S
SMILESO=S(=O)(NC)CC=1C=CC=2NC=C(C2C1)CCN(C)C
Target5-HT Receptor
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.17 mM);Ethanol:40 mg/mL (135.41 mM);DMSO:80 mg/mL (270.82 mM)

Bioactivity

Target IC50
5-HT1F Receptor:17.8 nM|5-HT1A Receptor:100 nM (Ki)|5-HT1D Receptor:17 nM (Ki)|5-HT1D Receptor:7.3 nM (IC50)|5-HT1B Receptor:27 nM (Ki)|5-HT1B Receptor:9.3 nM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Sumatriptan, 5HT Receptor, 5-HT1, 5HTReceptor, GR 43175 free base

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

10 mg
$ 70.00
1 ml x 10 mM (in DMSO)
$ 80.00
25 mg
$ 90.00
50 mg
$ 110.00
100 mg
$ 130.00
500 mg
$ 260.00
DispatchUsually dispatched within 5-10 working days
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