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SUN B8155

SKU: orb2944236

Description

SUN B8155 is a selective calcitonin receptor agonist that activates cAMP signaling in cells expressing the human CT receptor. It is a valuable research tool for studying calcitonin-mediated pathways in bone metabolism and calcium homeostasis, applicable in both cellular and animal models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number345893-91-6
MW273.29
Purity99.38%
FormulaC14H15N3O3
SMILESO=C1C=C(C(=C(O)N1O)C(=NC=2C=CC=CC2N)C)C
TargetCGRP Receptor
SolubilityDMSO:80 mg/mL (292.73 mM);10% DMSO+90% Saline:3.3 mg/mL (12.08 mM)

Bioactivity

Target IC50
cAMP:21 μM (EC50)
In Vivo
Intraperitoneal injection of SUN B8155 (100 mg/kg) resulted in a significant decrease in serum calcium concentration of approximately 9% at 30 minutes post-dose.
In Vitro
SUN B8155 (1-1000 μM, 1 hr treatment) promoted intracellular cAMP production in a concentration-dependent manner in T47D cells, with cAMP levels increasing approximately 42-fold at the highest concentration. The compound also increased cAMP production in the UMR106-06 cell line derived from rat osteogenic sarcoma. In CHO/hPTHR or CHO parental cells, SUN B8155 was unable to trigger cAMP production. However, in CHO/hCTR cells, SUN B8155 significantly enhanced cAMP generation in a concentration-dependent manner with an EC50 of 21 μM.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SUN-B 8155, SUN-B8155, SUN-B-8155, SUN B 8155, SUN B8155, SUN B-8155
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

SUN B8155 (orb2944236)

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% DMSO +
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% Tween 80 +
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2 mg
¥ 2,470.00
DispatchUsually dispatched within 5-10 working days
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