Suramin Sodium Salt

SKU: orb1306282

Description

Suramin Sodium Salt is a polysulphonated compound that inhibits tumor growth by blocking multiple growth factor receptors, including VEGF and PDGF, thereby suppressing angiogenesis and cell proliferation. It is widely used in oncology research, with applications in both in vitro studies of signaling pathways and in vivo models of cancer and parasitic diseases.

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Metabolism Research, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	129-46-4
MW	1429.15
Purity	99.33%
Formula	C₅₁H₃₄N₆Na₆O₂₃S₆
SMILES	[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Cc1ccc(cc1NC(=O)c1cccc(NC(=O)Nc2cccc(c2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(c3cc(cc(c23)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c1)C(=O)Nc1ccc(c2cc(cc(c12)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O
Target	Phosphatase,Topoisomerase,Reverse Transcriptase,Parasite,Sirtuin,SARS-CoV,Apoptosis
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (1.4 mM);DMSO:252.5 mg/mL (176.68 mM)

Bioactivity

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Target IC50	SIRT5:22 μM\|DNA topo II:5 μM\|SIRT1:297 nM\|SIRT2:1.15 μM
In Vivo	Treatment with suramin shows lower values for pulmonary artery pressure, right ventricular hypertrophy, and distal vessel muscularization on day 21 compared to control rats. Suramin treatment suppresses PA-SMC proliferation and attenuates both the inflammatory response and the deposition of collagen. Read more...
In Vitro	Suramin inhibits cell proliferation and DNA synthesis in cultured HeLa cells. The replication of SV40 DNA is completely abolished by 40 μM suramin. DNA polymerase α is sensitive to lower concentrations of suramin (IC50=8 μM) than is DNA polymerase δ (IC50=36 μM), whereas DNA polymerase β is relatively insensitive to the drug (IC50 of 90 μM). Suramin is a potent inhibitor of DNA strand exchange and ATPase activities of bacterial RecA proteins. Suramin inhibits RecA-catalysed proteolytic cleavage of the LexA repressor. The mechanism underlying such inhibitory actions of suramin involves its ability to disassemble RecA–single-stranded DNA filaments. Suramin is a potent inhibitor of the nuclear enzyme DNA topoisomerase II. Suramin inhibits purified yeast topoisomerase II with an IC50 of about 5 μM. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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phosphatases, Phosphatase, Sirtuin, protein-tyrosine, Topoisomerase, Topo II, Suramin, Suramin hexasodium, Suramin hexasodium salt, Suramin Sodium Salt, SARS-CoV, SARSCoV, SARS coronavirus, Reverse Transcriptase, ReverseTranscriptase, PTPases, DNA, BAY 205, BAY205, BAY-205, anti-angiogenic, antitrypanosomal, antiparasitic, anti-neoplastic, Apoptosis, Inhibitor, NF060, NF-060, NF 060, Parasite, inhibit, IP5K

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Compound Identifiers

PubChem CID

8514 ↗

Key Properties

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No computed properties available.

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