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SW106065

SKU: orb1298654

Description

SW106065 is a novel small molecule that induces apoptosis in malignant peripheral nerve sheath tumor (MPNST) cells by inhibiting ATP consumption, exhibiting an EC50 of 1 μM in vitro. It serves as a valuable research tool for investigating MPNST biology and potential therapeutic strategies in both cellular and animal models.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number62289-81-0
MW204.25
Purity99.97% (May vary between batches)
FormulaC10H8N2OS
SMILESO=C(Nc1cccnc1)c1cccs1
TargetApoptosis
SolubilityDMSO:96 mg/mL (470.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (16.16 mM)

Bioactivity

In Vivo
SW-106065 can reduce MPNST burden in a mouse allograft model, underscoring the compound's potential as a novel chemotherapeutic agent.
In Vitro
SW-106065 inhibits growth of all available in vitro models of MPNST and human MPNST cell lines, while remaining nontoxic to normally dividing Schwann cells or mouse embryonic fibroblasts. We This compound delays the cell cycle and leads to cellular apoptosis.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

cyclin, cycle, cell, cdk4, cdk6, anticancer, Apoptosis, apoptosis, ATP, Gliocidin, Inhibitor, MPNST, inhibit, SW 106065, SW106065, SW-106065
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

SW106065 (orb1298654)

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% Tween 80 +
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Available Sizes

Select a size below

1 mg
¥ 1,040.00
1 ml x 10 mM (in DMSO)
¥ 1,690.00
5 mg
¥ 1,690.00
10 mg
¥ 2,210.00
25 mg
¥ 3,510.00
50 mg
¥ 4,810.00
100 mg
¥ 6,630.00
DispatchUsually dispatched within 3-5 working days
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