SYVN1 (M) Antibody, Rabbit Polyclonal

SKU: orb67250

Description

Rabbit polyclonal to SYVN1.E3 ubiquitin-protein ligase synoviolin (SYVN1) is a multi-pass membrane protein that belongs to theHRD1 family. It acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically fromendoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting theirdegradation. SYVN1 protects cells from ER stress-induced apoptosis and protects neurons fromapoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promotingtheir degradation. It sequesters p53/TP53 in the cytoplasm and promotes its degradation, therebynegatively regulating its biological function in transcription, cell cycle regulation and apoptosis.

Images & Validation

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Tested Applications	WB
Dilution range	WB:1:500-1:2000
Reactivity	Human

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	middle region of human SYVN1
Molecular Weight	68
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Disclaimer	For research use only

Alternative Names

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anti-SYVN1 antibody,anti-E3 ubiquitinprotein ligase synoviolin antibody,anti-Synovial apoptosis inhibitor 1 antibody,anti-HRD1 antibody,anti-KIAA1810 antibody

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Western blot analysis of total cell extracts from human Hela using SYVN1 antibody

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UniProt

Q86TM6

UniProt Details

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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