TABERSONINE HYDROCHLORIDE

SKU: orb1301470

Description

Tabersonine hydrochloride, a natural alkaloid derived from Voacanga africana, is a potent inhibitor of Aβ(1-42) aggregation and its associated cytotoxicity. This compound is utilized in Alzheimer's disease research for in vitro studies investigating amyloid-beta toxicity and potential neuroprotective mechanisms.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Neuroscience, Protein Biochemistry, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	29479-00-3
MW	372.89
Purity	98.17% (May vary between batches)
Formula	C₂₁H₂₅ClN₂O₂
SMILES	Cl.[H][C@@]12N3CC[C@]11C(Nc4ccccc14)=C(C[C@]2(CC)C=CC3)C(=O)OC
Target	CDK,Akt,p38 MAPK,NOD-like Receptor (NLR),PI3K,NF-κB,Apoptosis,Cytochromes P450,Caspase,Beta Amyloid,Interleukin
Solubility	H2O:3 mg/mL (8.05 mM);DMSO:50 mg/mL (134.09 mM)

Bioactivity

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In Vivo

TABERSONINE HYDROCHLORIDE is an indole alkaloid mainly isolated from Catharanthus roseus, and a potential drug candidate for treatment of cancer and Alzheimer's disease (AD), however, its anti-inflammatory effect has not been revealed.TABERSONINE HYDROCHLORIDE ameliorated lipopolysaccharides (LPS)-induced ALI in vivo and inhibited LPS-mediated macrophage activation in vitro. By using murine ALI model, we found that TABERSONINE HYDROCHLORIDE significantly attenuated LPS-induced pathological injury in the lung. TABERSONINE HYDROCHLORIDE also inhibited LPS-mediated neutrophil infiltration, elevation of MPO activity and the production of TNF-α, IL-6 and IL-1β. Furthermore, TABERSONINE HYDROCHLORIDE inhibited LPS-induced the production of pro-inflammatory mediators such as iNOS, NO and cytokines by suppressing NF-κB and p38 MAPK/MK2 signaling cascades. TABERSONINE HYDROCHLORIDE HYDROCHLORIDE reduced the K63-linked polyubiquitination of TRAF6. Taken together,TABERSONINE HYDROCHLORIDE has anti-inflammatory activities in vitro and in vivo, and is a potential therapeutic candidate for the treatment of ALI/ARDS.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Beta Amyloid, BetaAmyloid, bAmyloid, b Amyloid, Aβ(1-42), Aβ, LI/ARDS, inhibit, Inhibitor, Tabersonine, TABERSONINE HYDROCHLORIDE, TABERSONINE Hydrochloride, βAmyloid, β Amyloid

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Compound Identifiers

PubChem CID

12443187 ↗

Key Properties

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No computed properties available.

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